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Periodontal Disease and the Role of Locally Administered Antimicrobials

Learning Objectives:

After hearing this audio clip, the listener should:

  • Understand the base line causes of periodontal disease, and know why it is such a difficult disease to treat
  • Know how locally administered antimicrobials (LAA) such as minocycline operate to eliminate periodontal disease causing bacteria

Millions of adult Americans suffer from progressive periodontitis. Periodontitis is a disease which is caused by the accumulation of harmful bacteria (known as red-complex bacteria) in and around periodontal pockets. Scaling and root planing are the standard means of controlling periodontal disease, however these methods may not be enough to eliminate bacterial colonies which can return to baseline levels quickly after the procedures are performed. When indicated, it is suggested that a treatment planning involving scaling and root planing be used in conjunction with locally administered antimicrobials, which have been shown to increase pocket depth reduction and reduce the number of harmful bacteria in periodontal pockets for up to 14 days.

Related Reading:

  1. http://thenextdds.com/Articles/Adjunctive-Therapy-to-Periodontal-Debridement/
  2. http://thenextdds.com/Articles/Management-of-Periodontal-Inflammations/
  3. http://thenextdds.com/Blogs/Periodontitis/Periodontitis---Intro-and-Treatment/
  4. Williams R, Paquette D, Offenbacher S, et al. Treatment of Periodontitis by Local Administration of Minocycline Microspheres: A Controlled Trial. J Periodontol. 2001; Vol72(11): 1535-1544.
  5. Meinberg T, Barnes C, Dunning D, Reinhardt R. Comparison of Conventional Periodontal Maintenance Versus Scaling and Root Planing with Subgingival Minocycline. J Periodontol. 2002; Vol73(2): 167-172.
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